ReFeel® Nerve Cuff Evaluation in Rat Sciatic Nerve Models

Thomas A. Russell's study compares the ReFeel® bioresorbable nerve cuff to commercial collagen-based devices in rat sciatic nerve models. The dataset includes functional, histological, immunohistochemical, and morphometric assessments at multiple time points up to 26 weeks. It was last updated on 2026-04-23 and is shared under a CC-BY-4.0 license.

Use Cases

• Compare biomaterial degradation rates based on scaffold resorption timelines mentioned in the description
• Analyze axon regeneration metrics based on quantitative scores for axon densities and G-ratios
• Evaluate host tissue response based on measures of fibrosis, inflammation, and fatty infiltration
• Benchmark novel nerve repair devices against commercial collagen-based conduits and wraps

Strengths

• Includes longitudinal data with assessments at 1, 8, 13, and 26 weeks
• Compares a novel device against two commercial benchmarks (NeuroMatrix® and NeuroMend®)
• Employs multiple assessment methods: functional, histological, immunohistochemical, and morphometric

Limitations

• Dataset is a 17.5 KB DOCX file, indicating a very small document rather than a large structured dataset
• Column-level documentation is absent; field semantics must be inferred after download
• Data is derived from a specific animal model (Sprague–Dawley rats), limiting direct human applicability

Provenance

Source

Thomas A. Russell via figshare

Collection Method

Experimental study in Sprague–Dawley rats using sciatic nerve gap and perineural wrap models

Time Range

Study duration up to 26 weeks

Freshness

Last updated 2026-04-23 10:18:54; freshness should be verified