Complement Activation Markers in Patients with Long COVID

A figshare-hosted clinical dataset contains measurements of complement activation markers C3bc, C3bBbP, and TCC from 128 subjects. The cohort includes 38 patients with Post-Acute Sequelae of SARS-CoV-2 (PASC) after mild initial infection, 10 PASC patients after severe infection, and 80 control subjects who recovered completely. The data was authored by Madlene Holmqvist and last updated in May 2026.

Use Cases

• Compare complement activation marker levels between PASC patients and recovered controls based on the described cohort.
• Investigate potential links between initial COVID-19 severity and subsequent complement dysregulation based on patient subgroups.
• Analyze trends in complement system activity up to 33 months post-infection based on the study's time frame.

Strengths

• Dataset includes measurements for three specific complement activation markers (C3bc, C3bBbP, TCC).
• Cohort is defined with specific group sizes: 38 mild PASC, 10 severe PASC, and 80 controls.
• Data is shared under a permissive CC-BY-4.0 license.

Limitations

• The dataset is very small at 25.2 KB, suggesting limited scope.
• Column-level documentation is absent; field semantics must be inferred after download.
• The study's conclusion notes no significant differences were found, which may limit its utility for finding strong signals.

Provenance

Source

figshare

Collection Method

Laboratory measurement of complement activation markers in a defined patient cohort.

Time Range

Measurements taken up to 33 months after initial SARS-CoV-2 infection.

Freshness

Last updated 2026-05-13 05:57:43; freshness should be verified.