Penicillin-Resistant Streptococcus Pneumoniae Genomics for Novel Target Identification

Indian clinical isolates of 665 penicillin-resistant Streptococcus pneumoniae genomes collected between 1996 and 2022 were analyzed by Avani Panickar. The dataset likely contains results from an in silico strategy integrating genomics, GWAS, network analyses, and membrane protein simulations to identify antimicrobial targets.

Use Cases

• Prioritizing novel drug targets based on essentiality screening and functional annotation mentioned in the description
• Analyzing evolutionary conservation of candidate genes across the 665 genomes
• Assessing druggability of protein structures based on structural modeling results
• Investigating transport-associated pathways linked to pneumococcal survival via network analysis

Strengths

• Focuses on 665 high-quality genome assemblies from a specific geographic region (India)
• Integrates multiple analysis methods (GWAS, network analysis, structural modeling) as described
• Has a clear temporal coverage spanning 26 years (1996-2022)

Limitations

• Column-level documentation is absent; field semantics must be inferred after download
• Row count is unknown, which may limit suitability assessment
• The dataset is very small (37.9 KB), suggesting limited scope or summary-level data

Provenance

Source

figshare

Collection Method

Genomic analysis of clinical isolates, likely from a research study.

Time Range

1996-2022

Freshness

Last updated 2026-04-29 05:54:27; freshness should be verified

Geography

India