Occupational Exposure Limits for 86 Small Molecule Kinase Inhibitors

86 FDA-approved small molecule kinase inhibitors (SMKIs) were analyzed for health hazard data to estimate occupational exposure limits (OELs). The dataset, compiled by Tyler Nicholas from literature and drug labels, includes data on genotoxicity, carcinogenicity, developmental toxicity, and therapeutic dose. Estimated OELs ranged from 0.05 to 96 µg/m³, with 82% falling between 1 and <100 µg/m³, and were mapped to occupational exposure bands (OEBs).

Use Cases

• Assigning occupational exposure bands (OEBs) based on estimated OELs and health hazard data.
• Evaluating risk by target family (e.g., JAK, FGFR, MEK inhibitors) for mechanism-informed safety protocols.
• Setting default exposure controls in data-limited drug development environments based on the derived OEL framework.

Strengths

• Includes health hazard data for 86 specific FDA-approved drugs.
• Provides a quantitative framework with estimated OELs spanning a defined range (0.05 to 96 µg/m³).
• Analysis maps results to standardized occupational exposure bands (OEB 2 and OEB 3A).

Limitations

• Row count and column-level documentation are absent; field semantics must be inferred after download.
• Dataset is very small (17.8 KB), indicating limited scope.
• Data may reflect bias inherent to the compiled literature and drug label sources.

Provenance

Source

Tyler Nicholas via figshare.

Collection Method

Compiled from literature sources and drug labels for 86 FDA-approved SMKIs.

Freshness

Last updated 2026-03-25 22:01:23; freshness should be verified.