ART Effects on Alveolar Macrophage Senescence and SARS-CoV-2 Response

A dataset from a systems immunology study investigating the long-term impact of continuous antiretroviral therapy (ART) on alveolar macrophages. The data likely contains transcriptomic and epigenetic profiles showing ART induces a progressive senescence-like pro-inflammatory state, with effects dependent on therapy duration. The dataset was authored by Vinicius M. Fava and last updated on April 22, 2026.

Use Cases

• Modeling the relationship between ART duration and macrophage senescence based on transcriptomic priming data.
• Analyzing gene regulatory networks linking pro-inflammatory transcription factors to ART-induced alterations.
• Investigating the impact of ART on interferon signaling and antiviral response to pathogens like SARS-CoV-2.
• Identifying potential targets for adjuvant therapies to mitigate adverse ART-effects on pulmonary immunity.

Strengths

• Data is derived from a systems immunology approach, likely integrating multiple 'omics' layers.
• Findings link ART duration to specific cellular states, suggesting a time-series component.
• Includes analysis of AM response to ex vivo SARS-CoV-2 challenge, providing a functional readout.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Description metadata is limited; actual data quality requires manual inspection after download.
• The sample source (people with HIV and on PrEP) may reflect a specific population bias.

Provenance

Source

figshare, author Vinicius M. Fava.

Collection Method

Likely generated via single-nucleus RNA sequencing and systems immunology analysis of alveolar macrophages from study participants.