Cost-Effectiveness of Single-Dose vs Two-Dose HPV Vaccination in Kenya and India

A Markov cohort model compares the cost-effectiveness of single-dose and two-dose HPV vaccination schedules in a composite low- and middle-income country setting derived from Kenya and India. The model tracks 100,000 girls aged 9 years over a lifetime horizon, estimating costs, disability-adjusted life years averted, and incremental cost-effectiveness ratios. The dataset was created by Jinyao Wang and uploaded to figshare in June 2026.

Use Cases

• Compare cost-effectiveness outcomes based on different vaccine protection duration assumptions.
• Analyze the impact of second-dose dropout rates on vaccination program efficiency.
• Model health outcomes like cases and deaths averted using a static Markov cohort framework.
• Evaluate incremental cost-effectiveness ratios against defined willingness-to-pay thresholds.

Strengths

• Model results are based on a cohort of 100,000 individuals tracked over a lifetime horizon.
• Analysis includes probabilistic sensitivity analysis with 10,000 simulations to characterize uncertainty.
• The model was assessed for face validity against observed incidence data.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is very small at 28.9 KB, indicating limited scope.
• The model uses a static direct-effect framework that does not capture herd immunity.

Provenance

Source

Jinyao Wang via figshare

Collection Method

Developed through static Markov cohort modelling.

Time Range

Lifetime horizon simulation from age 9 to 99.

Freshness

Last updated 2026-06-04 05:40:43; freshness should be verified.

Geography

Composite LMIC setting derived from Kenya (low-income) and India (lower-middle-income).