MPO-ANCA Vasculitis: B-Cell Repertoire and Epitope Data from Patient and Healthy Cohorts

A single-center study compares naturally occurring and disease-associated autoantibodies in MPO-ANCA vasculitis. The dataset includes bulk B cell receptor sequencing data from antigen-specific B cells and serum IgG epitope mapping results from patients with active disease, patients in long-term remission, and healthy individuals. Dhruti P. Chen authored this research, which was last updated on 2026-06-02.

Use Cases

• Compare B cell receptor clonotype diversity and clonal dominance between patient and healthy cohorts based on immunogenomic features described.
• Identify distinct MPO epitope signatures associated with disease using epitope mapping data from patient serum IgG.
• Analyze the overlap in CDR3 sequences among MPO-specific B cells from patients as mentioned in the results.
• Investigate the relationship between in vitro autoantibody production and BCR repertoire features described in the study.

Strengths

• Data was generated using highly sensitive methods to isolate MPO-specific B cells, as described.
• Includes matched BCR sequencing and epitope mapping data from the same cohort of patients and healthy individuals.
• Licensed under CC-BY-4.0, permitting open sharing and adaptation.

Limitations

• The dataset is small (428.2 KB), indicating limited scope.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.

Provenance

Source

figshare

Collection Method

Peripheral blood mononuclear cells were screened, B cells were sorted and expanded in vitro, followed by bulk BCR sequencing and serum IgG epitope mapping using a yeast surface display peptide library.

Freshness

Last updated 2026-06-02 08:12:24; freshness should be verified.

Geography

Data was collected from a single center; specific location is not stated.