DNER Drives Glycolytic Reprogramming in Renal Cell Carcinoma via JAK2/STAT3

An 814.2 KB Excel file from figshare, last updated May 22, 2026, by author Anrui Li. It contains bioinformatic and experimental data investigating the role of the DNER gene in clear cell renal cell carcinoma (ccRCC). The data supports findings that DNER promotes tumor progression by activating the JAK2/STAT3 signaling pathway to enhance glycolysis and influence the tumor microenvironment.

Use Cases

• Validate the correlation between DNER expression and metabolic pathway activity in ccRCC based on the described bioinformatic screening.
• Investigate the link between glycolytic flux and macrophage polarization in the tumor microenvironment based on the described signaling cascade.
• Explore potential associations between DNER overexpression and PARP inhibitor sensitivity in cancer cells based on the preliminary evidence mentioned.

Strengths

• Data integrates bioinformatic analyses with in vitro and in vivo experimental validation.
• Mechanistic studies focus on a specific signaling pathway (JAK2/STAT3) and downstream transcriptional targets (LDHA, PKM).
• Released under a permissive CC-BY-4.0 license for reuse.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is small in scale at 814.2 KB, indicating limited data volume.

Provenance

Source

figshare

Collection Method

Bioinformatic analyses integrated with experimental validation (in vitro and in vivo functional assays).

Freshness

Last updated 2026-05-22 06:09:50; freshness should be verified.