Table 2_Dose-dependent protective effects of Tripterygium wilfordii glycosides on joint an

Experimental data from a study of 6 groups of Wistar rats with collagen-induced arthritis, treated with varying doses of Tripterygium wilfordii glycosides (TWG). The dataset, uploaded by Shangwen Qi on 2026-04-23, likely contains measurements of joint and lung pathology, cytokine expression, and gut microbiota composition from animals sacrificed on day 43. Results indicate dose-dependent protective effects on joint and lung injury, associated with gut microbiota remodeling.

Use Cases

• Analyze dose-response relationships for herbal treatments based on the three TWG dose levels (9, 45, 90 mg/kg) and a prednisolone control.
• Model associations between gut microbiota composition and inflammatory markers based on 16S rRNA sequencing data and cytokine measurements (IL-6, TNF-α).
• Investigate correlations between histological scores for joint/lung injury and molecular biomarkers (TGF-β1, α-SMA) from Western blot analysis.
• Predict microbial functional pathways related to short-chain fatty acid production using PICRUSt2 inference results mentioned in the description.

Strengths

• Data is derived from a controlled animal experiment with 6 distinct treatment groups, including a normal control, model, and positive drug control.
• Multiple data modalities are integrated, including histopathology scores, gene expression (RT-qPCR), protein expression (Western blot), and 16S rRNA microbiome sequencing.
• The dataset has a clear temporal structure, with treatments administered from day 15 to 42 and a terminal endpoint on day 43.

Limitations

• Row count is unknown, which may limit suitability assessment for statistical modeling.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is very small (13.6 KB), indicating it likely contains summary or processed results rather than raw sequencing or image data.

Provenance

Source

figshare, uploaded by Shangwen Qi.

Collection Method

Data generated from a laboratory animal study using collagen-induced arthritis (CIA) in Wistar rats, with subsequent histological, molecular, and microbiome analyses.

Time Range

The experimental timeline covers from the induction of arthritis to sacrifice on day 43.

Freshness

Last updated 2026-04-23 05:27:24; freshness should be verified.