A table of extracellular matrix (ECM) remodeling features in reparative chondrocytes derived from integrated single-cell RNA sequencing of human knee cartilage. The dataset, 21.6 KB in size, was created by Fei Li and last updated on April 13, 2026. It supports a study on chondrocyte state transitions in knee osteoarthritis.
Use Cases
- Analyze ECM remodeling gene expression programs in reparative chondrocytes based on the description of collagen reorganization and FN1-integrin pathways.
- Model chondrocyte state transitions in osteoarthritis based on pseudotime trajectory inference described in the study.
- Investigate cell-cell communication networks in cartilage based on the inferred ECM-related interactions mentioned.
- Validate in vitro findings against single-cell signatures based on the described FN1 or TGF-β1 stimulation experiments.
Strengths
- Data is derived from integrated multiple publicly available single-cell RNA sequencing datasets, suggesting a unified cellular atlas.
- Dataset is openly licensed under CC-BY-4.0.
- Last update date is explicitly provided as 2026-04-13.
Limitations
- Row count and column definitions are unknown, limiting suitability assessment.
- Column-level documentation is absent; field semantics must be inferred after download.
- The dataset is very small at 21.6 KB, indicating a limited scope, likely a summary table.
Provenance
- Source
- figshare
- Collection Method
- Integrated analysis of multiple publicly available single-cell RNA sequencing datasets of human knee cartilage.
- Time Range
- null
- Freshness
- Last updated 2026-04-13 04:35:41; freshness should be verified.
- Geography
- null