Network Meta-Analysis of Diabetic Foot Ulcer Interventions from 24 RCTs

A network meta-analysis evaluates 15 non-pharmacological interventions for diabetic foot ulcer healing, based on 24 included randomized controlled trials. The study, authored by Jiaxing Zheng and published in 2026, compares interventions like Negative Pressure Wound Therapy and Gas Therapy on outcomes including 12-week healing rate and healing time.

Use Cases

• Compare the relative effectiveness of 15 intervention types, such as Negative Pressure Wound Therapy + Standard Care, on the 12-week healing rate outcome.
• Analyze the SUCRA rankings from the network meta-analysis to identify the most promising interventions for shortening healing time.
• Assess the risk of bias for the 24 included studies using the Cochrane RoB 2.0 tool evaluation mentioned in the methods.

Strengths

• Analysis is based on 24 randomized controlled trials, a systematic evidence base.
• Compares 15 distinct non-pharmacological intervention types for a specific clinical outcome.
• Uses a registered, systematic review methodology (PROSPERO CRD420251122143).

Limitations

• The evidence certainty is limited as noted by the authors, relying on a limited number of small-sample studies with wide confidence intervals.
• The dataset is a 18.4 KB document summarizing analysis results, not the underlying raw trial data.

Provenance

Source

Systematic review and network meta-analysis authored by Jiaxing Zheng, sourced from figshare.

Collection Method

Data extracted from 8 databases (PubMed, Embase, Cochrane, WOS, CNKI, Wanfang Data, CBM, VIP) following PICOS principles for study inclusion.

Time Range

null

Freshness

Last updated March 2026.

Geography

null