Meta-Analysis of Probiotic Effects on Diabetic Kidney Disease from 11 Randomized Trials

726 participants across 11 randomized controlled trials form the basis of this systematic review and meta-analysis. The study, authored by Zhi-Qing Huang and last updated in May 2026, evaluates the efficacy of probiotic supplementation for patients with diabetic kidney disease. It reports significant improvements in renal function, glycemic control, and inflammatory markers based on pooled data from seven major databases.

Use Cases

• Validate the impact of probiotics on serum creatinine and estimated glomerular filtration rate based on the reported meta-analysis results.
• Assess the effect of probiotic supplementation on glycemic parameters like fasting plasma glucose and HbA1c as described in the findings.
• Investigate the relationship between probiotics and inflammatory/oxidative stress markers such as hs-CRP and malondialdehyde.
• Inform the design of future clinical trials for diabetic kidney disease by reviewing the scope and outcomes of the included studies.

Strengths

• Includes data from 11 randomized controlled trials involving 726 participants, providing a quantitative synthesis.
• Reports specific mean differences and confidence intervals for key outcomes like serum creatinine (MD -0.17) and eGFR (MD 9.62).
• Systematically searched seven major databases including PubMed, Embase, and Cochrane Library up to July 2025.
• Study quality was assessed using the Cochrane Risk of Bias tool, indicating a structured methodological approach.

Limitations

• The primary data file is a 415 KB DOCX document; the underlying tabular data from the meta-analysis is not directly provided in a machine-readable format.
• Row count and column-level documentation for the aggregated trial data are unknown, limiting suitability assessment for direct computational analysis.
• The authors note that clinical efficacy and long-term effects require further validation in large-scale studies.

Provenance

Source

figshare

Collection Method

Systematic review and meta-analysis of randomized controlled trials identified from seven databases.

Time Range

Literature search from database inception to July 2025.

Freshness

Last updated 2026-05-20 05:44:19; includes literature search up to July 2025.