Efficacy and Safety of CPAP for Blood Pressure in Sleep Apnea

Jingjing Liu's overview includes 17 systematic reviews and meta-analyses on CPAP therapy for obstructive sleep apnea. The analysis assesses methodological quality, evidence certainty, and citation overlap, with 14 of the 17 reviews rated as low quality. It compiles findings from databases like PubMed and Cochrane up to December 2025.

Use Cases

• Analyze the distribution of GRADE evidence certainty ratings (high, moderate, low, very low) across outcomes from the included reviews.
• Assess the correlation between AMSTAR-2 methodological quality ratings and the reported blood pressure outcomes in the 17 reviews.
• Investigate the citation overlap matrix and corrected coverage area (14.2%) to understand redundancy in the underlying primary studies.
• Compare the number of high-quality reviews (3) against those with low quality (14) to evaluate the reliability of the field's conclusions.

Strengths

• Includes 17 systematic reviews and meta-analyses, providing a consolidated view of the evidence.
• Employs multiple standardized assessment tools (ROBIS, AMSTAR-2, PRISMA 2020, GRADE) for quality evaluation.
• Quantifies citation overlap with a corrected coverage area of 14.2%, highlighting study redundancy.
• Provides a detailed GRADE assessment breakdown: 4 high, 29 moderate, 51 low, and 25 very low certainty outcomes.

Limitations

• The dataset is a single 541.5 KB DOCX file, limiting structured analysis and automated processing.
• A significant majority (14 out of 17, or 82.3%) of the included reviews were assessed as having low methodological quality.
• The evidence certainty is predominantly low-to-very-low, with only 4 outcomes rated as high quality.

Provenance

Source

Author Jingjing Liu, published on figshare.

Collection Method

Umbrella review compiling systematic reviews and meta-analyses from PubMed, Embase, Cochrane Library, Web of Science, CNKI, VIP, Wanfang, and CBM databases.

Time Range

Literature search from database inception to December 1, 2025.

Freshness

Last updated March 24, 2026, with literature search current to December 1, 2025.

Geography

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