Meta-Analysis of Thymosin Efficacy and Safety in Esophageal Cancer Treatment

Table 2_Efficacy and safety of thymosin combined with anticancer therapy for esophageal cancer: a systematic review and meta-analysis of randomized controlled trials.docx is a dataset containing aggregated results from a meta-analysis of 18 randomized controlled trials involving 1,272 patients. The analysis, conducted by Tao Sun and published on figshare in 2026, evaluates the impact of thymosin combined with standard anticancer therapy on clinical outcomes, immune function, and adverse effects for esophageal cancer.

Use Cases

• Compare objective response rates (ORR) between thymosin combination therapy and standard therapy alone.
• Analyze changes in immune function markers like CD3+, CD4+, and NK cell levels from combined treatment.
• Assess the reduction in adverse effects such as leukopenia and radiation esophagitis with combination therapy.
• Evaluate survival rate improvements at 1-year, 2-year, and 3-year intervals.
• Validate meta-analysis findings using Trial Sequential Analysis (TSA) and GRADE evidence quality assessments.

Strengths

• Aggregates data from 18 randomized controlled trials with a total of 1,272 patients.
• Reports specific risk ratios and confidence intervals for multiple efficacy and safety outcomes.
• Includes a detailed assessment of evidence quality using the GRADE system.
• Conducts sensitivity analysis and publication bias assessment using Stata 18.0.

Limitations

• The methodological quality of the included RCTs is described as limited, and publication bias is noted.
• The dataset is a single 23.5 KB DOCX file; its internal structure and column-level data are unknown.
• The GRADE assessment indicates the quality of evidence for most outcomes ranges from 'very low' to 'low'.

Provenance

Source

Tao Sun via figshare.

Collection Method

Systematic review and meta-analysis of randomized controlled trials from Chinese and English databases.

Freshness

Last updated 2026-05-29 06:13:11.