Multi-Omics Data on Daifu Decoction Effects in Ulcerative Colitis

A 9.5 KB Excel file contains tabular data from a multi-omics study investigating the molecular mechanisms of Daifu decoction in treating ulcerative colitis. The dataset includes results from transcriptomics, metabolomics, and 16S rRNA sequencing analyses of a mouse model. It was authored by Yangyang Zhao and published on figshare in 2026 under a CC BY 4.0 license.

Use Cases

• Analyze transcriptomics data to identify gene expression changes, such as PRKCG, associated with ulcerative colitis treatment.
• Correlate 16S rRNA sequencing results with clinical outcomes to assess changes in gut microbiota diversity and beneficial bacterial proportions.
• Integrate metabolomics and transcriptomics findings to explore the PKCγ/ERK/NF-κB signaling pathway regulation.
• Use molecular docking and dynamics simulation data to validate interactions between active components of Daifu decoction and the PRKCG target.

Strengths

• Data integrates multiple omics layers (transcriptomics, metabolomics, 16S rRNA sequencing) for a systems-level analysis.
• Includes experimental verification through molecular docking, dynamics simulations, qPCR, and western blotting.
• Dataset is openly available under a permissive CC BY 4.0 license.

Limitations

• The dataset is very small at 9.5 KB, indicating limited scope and likely a summary of key findings rather than raw experimental data.
• Data is derived solely from a mouse model, limiting direct applicability to human ulcerative colitis.
• Specific row and column counts, sample sizes, and data granularity are not provided in the input.

Provenance

Source

figshare, authored by Yangyang Zhao.

Collection Method

Generated from a laboratory study using a DSS-induced ulcerative colitis mouse model treated with Daifu decoction, analyzed via multi-omics techniques and experimental verification.

Time Range

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Freshness

Last updated in March 2026.

Geography

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