Emapunil Attenuates Ulcerative Colitis: ZBP1 and Macrophage Data

A 284.8 KB Excel file published on figshare by Shenghao Xv on May 26, 2026. It contains experimental data from a study investigating the role of Z-DNA binding protein 1 (ZBP1) in ulcerative colitis and the therapeutic mechanism of the drug candidate Emapunil. The data likely includes results from in vitro and in vivo experiments analyzing macrophage pyroptosis, polarization, NF-κB pathway activation, and intestinal barrier function.

Use Cases

• Validate ZBP1 as a therapeutic target for ulcerative colitis based on its role in macrophage pyroptosis described in the study.
• Analyze the anti-inflammatory effects of Emapunil based on its suppression of ZBP1-driven macrophage polarization.
• Investigate the relationship between macrophage pyroptosis and intestinal barrier integrity using the experimental results.
• Study the TSPO-targeting mechanism of a drug candidate for inflammatory bowel disease.

Strengths

• Data is directly linked to a specific mechanistic study on ZBP1 and Emapunil, providing clear biological context.
• The dataset is openly available under a CC-BY-4.0 license, permitting reuse with attribution.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is small (284.8 KB), indicating limited scope or summary-level data.

Provenance

Source

figshare

Collection Method

Data generated from laboratory experiments including immunofluorescence, gene overexpression/knockdown, and in vivo mouse models.

Freshness

Last updated 2026-05-26 04:39:14; freshness should be verified.