Genomic Analysis of a Virulent Carbapenem-Resistant Klebsiella Clone

Guiling Li's research article characterizes a carbapenem-resistant Klebsiella pneumoniae ST15-KL19 clone with elevated virulence, isolated from a tertiary hospital in eastern China. The 19.5 KB document presents genomic and phenotypic analysis results, including whole-genome sequencing and phylogenetic data. It was last updated in April 2026.

Use Cases

• Analyze the conserved chromosomal virulence-associated gene profile to understand pathogenicity mechanisms.
• Study the hybrid plasmids carrying multiple resistance determinants, such as blaKPC-2, to map resistance gene co-localization.
• Use phylogenetic analysis results to trace clonal expansion and local dissemination relative to other Chinese ST15-KL19 strains.
• Examine the stable composite transposon structure housing blaKPC-2 to assess genetic mobility and maintenance potential.

Strengths

• Document provides specific genomic findings for a high-risk bacterial clone (ST15-KL19).
• Includes analysis of multiple resistance determinants and a virulence profile.
• Data is recent, with a last update in 2026.

Limitations

• Dataset is a 19.5 KB text document, not a structured data table, limiting computational analysis.
• Sample size and number of isolates analyzed are not specified.
• Geographic coverage is limited to a single hospital in eastern China.

Provenance

Source

Guiling Li, via figshare.

Collection Method

Phenotypic characterization and whole-genome sequencing of bacterial isolates.

Time Range

null

Freshness

Last updated April 2026.

Geography

A tertiary hospital in eastern China.