Ellen Caroline Nobre Santos published experimental data on figshare in 2026. The dataset compares the virulence and neuroinvasion of contemporary Oropouche virus (OROV) reassortant isolates from 2024 against a historical prototype strain in the AG129 mouse model. It provides evidence for increased pathogenicity in recent OROV lineages.
Use Cases
- Compare viral load and dissemination patterns based on organ-specific viral titers mentioned in the description
- Analyze disease progression and mortality rates based on the comparison of contemporary and historical virus strains
- Study inflammatory responses to infection based on the upregulation of IL-1β across tissues
- Model the enhanced neuroinvasion capacity of reassortant OROV lineages based on brain viral load data
Strengths
- Directly compares two 2024 OROV isolates (SC2024 and AC2024) against a historical prototype (BeAn19991)
- Measures viral loads across multiple organs including spleen, kidney, liver, lung, uterus, testes, and brain
- Includes data on viremia, disease progression, mortality, and pro-inflammatory cytokine response
Limitations
- Dataset is very small at 2.0 KB, indicating limited scope
- Row count and column-level documentation are unknown; field semantics must be inferred after download
Provenance
- Source
- figshare
- Collection Method
- Experimental data from a mouse model study.
- Time Range
- Focuses on 2024 virus isolates compared to a historical strain.
- Freshness
- Last updated 2026-05-19 05:41:53
- Geography
- Isolates are from non-Amazonian (SC2024) and Amazon Basin (AC2024) regions.