Systematic Review and Meta-Analysis on Endocrine Disruptors and Endometrial Cancer Risk

A meta-analysis of 14 studies found higher cadmium exposure was associated with a 22% increased risk of endometrial cancer. Lutian Gong published this systematic review summarizing evidence on cadmium, PCBs, PFAS, phthalates, and bisphenols up to November 30, 2025. The document file is 73.0 KB and was last updated on May 28, 2026.

Use Cases

• Conducting a meta-analysis on cadmium exposure and endometrial cancer risk based on the included 14 studies.
• Summarizing emerging evidence on PFAS, phthalates, and bisphenols for narrative review.
• Performing subgroup analyses on cadmium exposure stratified by menopausal status or hormone therapy.

Strengths

• Includes a quantitative meta-analysis for cadmium and PCBs with reported risk ratios and confidence intervals.
• The review covers multiple classes of endocrine-disrupting chemicals (cadmium, PCBs, PFAS, phthalates, bisphenols).
• Statistical analyses were performed using Stata 18.0, and the document is licensed under CC-BY-4.0 for open access.

Limitations

• The dataset is a 73.0 KB DOC file containing a review article, not a primary data table; column-level documentation is absent.
• Row count is unknown, which may limit suitability assessment for direct data extraction.
• Quantitative synthesis was not feasible for PFAS, phthalates, or bisphenols due to a limited number of available studies.

Provenance

Source

figshare

Collection Method

Systematic review and meta-analysis of studies from PubMed, Web of Science, EMBASE, and Cochrane Library.

Time Range

Studies published up to November 30, 2025.

Freshness

Last updated 2026-05-28 04:51:57; freshness should be verified.