Blood DNA Methylation and Physical Fitness Associations in Healthy Adults

A cohort of healthy adults was analyzed for associations between blood DNA methylation at approximately 730,000 CpG sites and three physical fitness indicators: estimated VO₂max, grip strength, and vertical jump height. The dataset contains results from epigenome-wide association analyses adjusted for age, sex, and blood cell composition, authored by Ferenc Torma and last updated in April 2026. No significant single-CpG associations were found, but differential methylation was identified when participants were stratified by VO₂max norms.

Use Cases

• Identify subtle epigenetic markers associated with cardiorespiratory fitness based on VO₂max stratification.
• Investigate differential methylation regions (DMRs) related to metabolic and inflammatory pathways.
• Perform hypothesis-generating analysis on links between grip strength, vertical jump, and DNA methylation patterns.
• Replicate and validate findings on specific CpG sites like cg21308111 (TNFRSF10A) and cg17890932 (USP24) in independent cohorts.

Strengths

• Analyzes a high-resolution set of approximately 730,000 CpG sites using the Illumina MethylationEPIC array.
• Statistical analyses were adjusted for age, sex, estimated blood cell composition, and multiple testing.
• Results include specific differentially methylated CpG sites identified at a false discovery rate (FDR < 0.05).

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The authors note findings are hypothesis-generating and require confirmation in larger, independent cohorts.

Provenance

Source

figshare, author Ferenc Torma.

Collection Method

Illumina MethylationEPIC array analysis on a cohort of healthy adults, with epigenome-wide association studies.

Time Range

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Freshness

Last updated 2026-04-15 11:53:12; freshness should be verified.

Geography

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