Göttingen Minipig Urinary Tract Infection Model Data and Strain Characterization

A 2026 study by Joyce Lübbers describes a novel intraurethral urinary tract infection model in Göttingen minipigs using uropathogenic E. coli strain UTI89. The dataset includes results from bacterial enumeration, agglutination testing, and whole genome sequencing of recovered strains over a 14-day infection period. It is shared under a CC-BY-4.0 license on figshare.

Use Cases

• Validating animal model fidelity based on strain recovery and characterization data
• Assessing vaccine efficacy in preclinical models based on bacterial enumeration outcomes
• Evaluating antibiotic treatment effects based on infection persistence data
• Studying strain identity and contamination in infection models based on whole genome sequencing results

Strengths

• Includes whole genome sequencing data for recovered bacterial strains
• Reports specific infection duration (14 days) and strain recovery rates (75% UTI89, 25% other E. coli)
• Provides detailed methodological description of intraurethral challenge and sample collection

Limitations

• Dataset is small (36.1 KB) and consists of a single document, limiting scope
• Column-level documentation is absent; field semantics must be inferred after download
• Row count is unknown, which may limit suitability assessment

Provenance

Source

figshare

Collection Method

Experimental study involving intraurethral bacterial challenge, urine collection, plating, agglutination testing, and whole genome sequencing.

Freshness

Last updated 2026-05-18 05:45:00; freshness should be verified