Estrogen Signaling Processes in Fibroblasts: A Scoping Review

67 eligible studies were identified through a systematic search across PubMed, Scopus, and EMBASE. The review maps evidence on estrogen, phytoestrogens, and SERMs affecting fibroblast signaling via ERα, ERβ, and GPER. Author Neena Roy published the review document on figshare in March 2026.

Use Cases

• Summarizing evidence on estrogen's anti-fibrosis effects based on the review's findings
• Identifying gaps in sex-specific fibroblast response research based on the described limitations
• Mapping receptor-specific pathways (ERα, ERβ, GPER) in fibroblasts based on the described signaling mechanisms
• Analyzing the role of ligands like phytoestrogens and SERMs in cancer-associated fibroblasts based on the paracrine effects described

Strengths

• Systematic search across three major databases (PubMed, Scopus, EMBASE)
• Identified 67 eligible studies for analysis
• Published under an open CC-BY-4.0 license

Limitations

• The dataset is a 678.6 KB DOCX document, which suggests limited scope and is not a structured data table
• Row count and column-level documentation are absent; field semantics must be inferred after download
• The description notes significant gaps in the reviewed literature, including small sample sizes and lack of mechanistic detail

Provenance

Source

figshare

Collection Method

Systematic scoping review conducted via Covidence screening

Freshness

Last updated 2026-03-19 08:22:54