Influenza A(H1N1) Evolutionary Trajectory and Co-detection Analysis (2000-2025)

An evidence-mapping synthesis integrates bibliometric analysis, expert curation, and sequence data to characterize the evolutionary dynamics and reported co-detections of human influenza A(H1N1) virus. The work is based on 11,848 unique publications retrieved from PubMed, Web of Science, and Scopus, alongside GenBank-derived hemagglutinin sequences. The dataset was authored by Xinrui Cao and published on figshare in March 2026.

Use Cases

• Identify recurrent hemagglutinin substitutions like S13, S146, S160, and S202 to track post-2010 mutational shifts.
• Analyze literature-derived co-detection records to compare reported frequencies of co-pathogens such as RSV and SARS-CoV-2.
• Examine the conformationally flexible HA segment spanning residues aa190–aa226 for structural insights into the receptor-binding microenvironment.
• Investigate the G219A mutation in Eurasian avian-like H1N1 strains as a hypothesis-generating site within the receptor-binding region.
• Use the integrated bibliometric and sequence data to inform a tiered, method-aware framework for multi-pathogen surveillance.

Strengths

• Analysis is based on 11,848 unique, deduplicated publications from major databases (PubMed, Web of Science, Scopus).
• Integrates multiple data types: bibliometric records, GenBank HA sequences, Swiss-Model homology structures, and expert annotations.
• Covers a 25-year temporal range (2000–2025) for longitudinal analysis of research and viral evolution.

Limitations

• The dataset is a 58.6 KB DOCX file containing a synthesis report, not the underlying raw data (sequences, publication records).
• Literature-derived co-detection proportions reflect heterogeneous study reporting composition, not population-level prevalence.
• Specific sample sizes for sequence data and co-detection records are not provided within the description.

Provenance

Source

Publications from PubMed, Web of Science, and Scopus; HA sequences from GenBank.

Collection Method

Evidence-mapping synthesis integrating bibliometric analysis, expert-guided curation, and sequence/structure-informed interpretation.

Time Range

2000–2025

Freshness

Last updated March 2026, providing recent analysis.

Geography

Global scope with a specific China-focused module for certain strain analysis.