Glycerophospholipid Metabolism in Nasopharyngeal Carcinoma: Multi-Omics Analysis

A multi-omics analysis of nasopharyngeal carcinoma (NPC) tissues integrates single-cell transcriptomics, spatial transcriptomics, and spatial metabolomics. The dataset, authored by Liping Wang and last updated in May 2026, identifies five glycerophospholipid-related genes and explores interactions between malignant epithelial cells and CCL11-expressing fibroblasts. It is a small dataset, 15.1 KB in size, shared under a CC-BY-4.0 license.

Use Cases

• Identifying diagnostic or prognostic biomarkers based on the five identified glycerophospholipid-related genes (AGPAT3, DGAT2, SLC44A1, AGPAT5, LPGAT1).
• Modeling metabolic interactions within the tumor microenvironment based on the interplay between malignant epithelial cells and fibroblasts.
• Analyzing spatial gene expression patterns during tumor invasion based on the spatial trajectory analysis mentioned in the description.
• Investigating the role of CCL11-expressing fibroblasts in fatty acid accumulation and glycerophospholipid metabolism.

Strengths

• Integrates three complementary omics layers: single-cell transcriptomics, 10x spatial transcriptomics, and spatial metabolomics.
• Identifies five specific glycerophospholipid-related genes (AGPAT3, DGAT2, SLC44A1, AGPAT5, LPGAT1) with differential expression.
• Shared under a permissive CC-BY-4.0 license, allowing for broad reuse and adaptation.

Limitations

• Row count is unknown, which may limit suitability assessment for large-scale analyses.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is very small (15.1 KB), indicating limited scope, likely containing summary results rather than raw data.

Provenance

Source

figshare, authored by Liping Wang.

Collection Method

Multi-omics approach integrating single-cell transcriptomics, 10x spatial transcriptomics, and spatial metabolomics on NPC tissues.

Freshness

Last updated 2026-05-20 05:47:46; freshness should be verified.