Lipidomic Profiles from 13 PDAC Patients via EUS-FNA Biopsy

A lipidomic analysis of paired tumor and adjacent non-tumor tissues from 13 pancreatic ductal adenocarcinoma (PDAC) patients, collected via endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA). The dataset, authored by Shenhao Liu and last updated in May 2026, contains measurements of 1,822 lipid species across 47 lipid classes, generated using liquid chromatography–tandem mass spectrometry (LC–MS/MS). An independent cohort of serum samples from 30 PDAC patients is also included for exploratory projection.

Use Cases

• Identify differential lipid species between tumor and non-tumor tissues based on the 1,822 lipid species measured.
• Construct composite lipid scores for diagnostic potential based on principal component loadings mentioned in the description.
• Investigate patterns of fatty acyl chain elongation and unsaturation described in the tumor tissue lipid remodeling.
• Explore the translational feasibility of lipidomic profiling in EUS-FNA-derived diagnostic samples as described.
• Perform exploratory projection analysis to compare tissue lipid alterations with directionally consistent changes in serum samples from the independent cohort.

Strengths

• Includes paired tumor and adjacent non-tumor tissue samples from 13 patients, enabling within-patient comparisons.
• Profiles a large number of lipid features, with 1,822 species across 47 lipid classes detected.
• Uses a clinically relevant sample collection method (EUS-FNA), supporting translational research potential.
• Includes an independent validation cohort of serum samples from 30 PDAC patients for exploratory analysis.

Limitations

• Row count and column-level documentation are unknown, which may limit suitability assessment and require manual inspection.
• The sample size of the primary tissue cohort is relatively small (13 patients).
• Description metadata is limited; actual data quality and field semantics must be inferred after download.

Provenance

Source

figshare, author Shenhao Liu.

Collection Method

Paired tumor and adjacent non-tumor tissues obtained via endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA), analyzed by widely targeted (pseudo-targeted) liquid chromatography–tandem mass spectrometry (LC–MS/MS).

Freshness

Last updated 2026-05-29 04:46:55; freshness should be verified.