Serum Proteome Dose-Response in Healthy Dogs Following Cannabidiol Administration

Proteomic data compares the serum protein responses of 18 healthy dogs after 30 days of oral cannabidiol (CBD) delivery via three distinct matrices: hemp by-product feed pellets, CBD-infused oil, and a semi-solid treat. The dataset, uploaded by Wutthiwong Theerapan on figshare in 2026, reveals formulation-specific signatures and a shared core metabolic response involving apolipoproteins and hemoglobin subunits. Findings demonstrate that the CBD delivery matrix critically influences systemic bioavailability and the scope of proteomic remodeling.

Use Cases

• Compare proteomic signatures between different CBD delivery matrices (feed pellets, oil, treats) based on the described formulation-specific responses.
• Investigate CBD-mediated modulation of lipid metabolism based on the downregulation of apolipoproteins (APOA4, APOC3, APOC1, APOH) mentioned in the description.
• Analyze markers of vascular integrity and tissue scaffolding (e.g., TGFB1, PDGFRB, VWF) in high-exposure CBD groups.
• Study immunomodulatory and cytoprotective markers, such as clusterin (CLU), in specific formulation groups.
• Model the relationship between CBD bioavailability and proteomic remodeling pathways described in the study.

Strengths

• Includes data from 18 healthy dogs across three distinct CBD delivery formulations.
• Employs label-free quantitative proteomics, a method mentioned in the description.
• Contains specific protein markers (e.g., APOA4, HBA, TGFB1) identified in the analysis.
• Released under a permissive CC-BY-4.0 license.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is small (131.2 KB), indicating limited scope.

Provenance

Source

figshare

Collection Method

Label-free quantitative proteomics analysis of canine serum samples.

Time Range

Study period not specified; data reflects a 30-day administration period.

Freshness

Last updated 2026-05-13 05:55:53; freshness should be verified.