Herpes Zoster Pain Outcomes Linked to VZV Genotypes and gE Mutations

52 herpes zoster outpatients from Chongqing were enrolled, with 46 samples sequenced for varicella-zoster virus genotypes and glycoprotein E mutations. Ying Shi authored this study, which integrates viral genotypic features, host immune markers, and clinical data to build a predictive model for pain outcomes. The dataset was last updated on April 29, 2026.

Use Cases

• Predicting poor pain relief outcomes based on gE-related variables and immunological markers mentioned in the description
• Analyzing associations between VZV genotypes (e.g., Clade 2) and clinical pain outcomes
• Investigating the role of specific gE mutation patterns (e.g., T→I substitution) in disease progression
• Building L1-regularized regression models for clinical stratification using integrated viral and host data

Strengths

• Includes 46 sequenced samples with detailed viral genotype and mutation analysis
• Integrates multiple data types: clinical outcomes, immunological indicators (gE antigen/antibody, IgG, complement, CD4+ T cells), and viral genetic features
• The predictive model for pain outcomes demonstrated reported performance metrics (AUC=0.87)

Limitations

• Row count is unknown, which may limit suitability assessment
• Column-level documentation is absent; field semantics must be inferred after download
• Data reflects a specific geographic bias, originating from a cohort of 52 outpatients in Chongqing

Provenance

Source

figshare

Collection Method

Clinical data and immunological indicators were collected from herpes zoster outpatients; viral genotyping and gE mutation analysis were performed via SNP analysis, PCR, and sequencing.

Freshness

Last updated 2026-04-29 05:58:10; freshness should be verified

Geography

Chongqing, China