Gene-Environment Interactions for Osteoporosis Risk in 609 Mexican Women

A 2026 case-control study of 609 Mexican women (169 with osteoporosis, 205 with hip fracture, 235 controls) by Antonio Miranda-Duarte. It analyzes single-nucleotide variants in genes like ESR1, RANK, IL6, and their interactions with environmental factors to assess osteoporosis and hip fracture risk using real-time PCR and multifactor dimensionality reduction.

Use Cases

• Identify genetic risk factors for osteoporosis based on specific SNVs in ESR1, RANK, and other genes.
• Model gene-gene interactions for hip fracture risk using the described ESR1, IL6R, IL1β, and RANKL model.
• Analyze gene-environment interactions involving CYP19A1 variants and 10-year fracture probability.
• Validate genetic association findings (e.g., odds ratios for RANK rs3018362) in a Mexican female cohort.

Strengths

• Includes specific odds ratios and confidence intervals for key genetic associations (e.g., RANK rs3018362 OR=2.76).
• Reports cross-validation consistency (CVC) scores for interaction models (e.g., 10/10 for an osteoporosis model).
• Focuses on an understudied demographic group (Mexican women) with clear case/control counts.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data may reflect geographic and demographic bias inherent to the single cohort study.

Provenance

Source

Antonio Miranda-Duarte via figshare.

Collection Method

Case-control study using real-time PCR with TaqMan probes and multifactor dimensionality reduction (MDR) software.

Time Range

Study date not specified; dataset reflects a single time point analysis.

Freshness

Last updated 2026-03-18 10:17:55; freshness should be verified.

Geography

Mexican women.