Genetic Determinants of AMD in Middle Eastern Populations: A Systematic Review

Middle Eastern populations from five countries are covered in this systematic review of genetic variants associated with age-related macular degeneration (AMD). The dataset summarizes evidence from 28 studies covering 4,247 AMD cases and 3,447 controls, focusing on genes like CFH, ARMS2, and HTRA1. It was authored by Naif S. Sannan and last updated in May 2026.

Use Cases

• Conducting meta-analysis on AMD-associated genetic variants based on reported odds ratios and p-values.
• Comparing genetic risk factor prevalence across populations based on the coverage of five Middle Eastern countries.
• Identifying research gaps in AMD genetics based on the review's conclusion about incomplete characterization in the region.

Strengths

• Includes data from 28 studies covering 4,247 AMD cases and 3,447 controls.
• Provides specific metrics for key variants, such as odds ratios ranging from 0.36 to 17.34 for the CFH Y402H variant.
• Clear geographic scope covering five Middle Eastern countries: Turkey, Iran, Israel, Jordan, and Egypt.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is small (165.1 KB), suggesting it contains summary-level data rather than raw genetic data.

Provenance

Source

figshare

Collection Method

Systematic literature review from PubMed, Web of Science, and Medline.

Time Range

No restrictions on year of publication for included studies.

Freshness

Last updated 2026-05-07 22:01:47; freshness should be verified.

Geography

Middle Eastern populations (Turkey, Iran, Israel, Jordan, Egypt).