Gene Expression Analysis of lncRNAs in Primary Sjögren's Syndrome

A genome-wide gene expression dataset from 126 minor salivary gland samples, including 92 from patients with primary Sjögren's syndrome and 34 from non-Sjögren's controls. The data was generated by Zhongshan Li using deep stranded total transcriptome sequencing and was last updated in April 2026. It includes a constructed competing endogenous RNA network comprising 3,035 lncRNAs and 10,838 coding genes.

Use Cases

• Constructing competing endogenous RNA networks based on shared miRNA binding sites and gene expression correlations.
• Identifying differentially expressed genes between patient and control groups for biomarker discovery.
• Investigating the regulatory roles of specific lncRNAs like BISPR, LINC00926, and HCP5 in disease pathways.
• Validating predicted lncRNA functions through in vitro experiments in salivary gland cell lines.

Strengths

• Includes data from 126 human tissue samples (92 patients, 34 controls).
• Contains a constructed genome-wide ceRNA network with 3,035 lncRNAs and 10,838 coding genes.
• Experimental validation was performed for three key lncRNAs, linking them to clinical features.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.

Provenance

Source

figshare

Collection Method

Deep stranded total transcriptome sequencing performed on minor salivary gland biopsies.

Time Range

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Freshness

Last updated 2026-04-15 05:33:19; freshness should be verified.

Geography

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