Genomic Analysis of Cefiderocol Resistance in Klebsiella pneumoniae from UAE

A genomic analysis of 282 Klebsiella pneumoniae strains from the United Arab Emirates, with 96 subjected to whole-genome sequencing. The dataset correlates mutations in oxidative stress, iron regulation, and efflux pump pathways with susceptibility to the antibiotic cefiderocol. It was authored by Lana Daoud and last updated in May 2026.

Use Cases

• Identify genetic biomarkers for cefiderocol resistance based on mutations in iron uptake genes like cirA.
• Analyze co-mutation networks linking oxidative stress, efflux, and DNA repair pathways to antibiotic susceptibility.
• Investigate the genomic evolution of high-risk Klebsiella pneumoniae clones (e.g., ST14, ST147) in a specific region.
• Study the paradoxical relationship between intact oxidative stress defenses and reduced antibiotic efficacy.

Strengths

• Includes phenotypic susceptibility data for 282 bacterial strains tested against multiple antibiotics.
• Provides whole-genome sequencing data for 96 representative isolates, enabling detailed genotypic analysis.
• Focuses on a specific, high-priority research question linking multi-pathway mutations to a novel antibiotic.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data may reflect geographic bias inherent to the collection from the United Arab Emirates.

Provenance

Source

figshare

Collection Method

Whole-genome sequencing and bioinformatic analysis of 96 representative strains from a collection of 282.

Freshness

Last updated 2026-05-15 05:27:53; freshness should be verified.

Geography

United Arab Emirates