GLIS3 Expression and Prognosis in Stomach Adenocarcinoma

Qi Xiao's research dataset includes GLIS3 expression and clinical association data for stomach adenocarcinoma. It likely contains transcriptomic data from The Cancer Genome Atlas, Genotype-Tissue Expression, and Gene Expression Omnibus, alongside immunohistochemistry results from 133 paired STAD tissues. The dataset was last updated on 2026-05-21.

Use Cases

• Assess GLIS3 as a prognostic biomarker for survival based on its association with adverse clinicopathological features.
• Investigate the link between GLIS3 expression and epithelial-mesenchymal transition marker switching.
• Study the relationship between GLIS3, TGFBR3, and Hedgehog signaling pathway activity.
• Validate gene expression findings against protein-level immunohistochemistry data from clinical samples.

Strengths

• Includes data from multiple public transcriptomic datasets (TCGA, GTEx, GEO).
• Contains protein-level validation from 133 paired clinical tissue samples.
• Clinical associations are supported by multivariable Cox models with hazard ratios (e.g., HR=1.45).

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is very small (17.3 KB), suggesting it contains summary or supplementary data rather than raw experimental results.

Provenance

Source

figshare, author Qi Xiao

Collection Method

Analysis of public transcriptomic datasets and immunohistochemistry on a clinical cohort.

Freshness

Last updated 2026-05-21 04:19:29; freshness should be verified.