GPX2+ Tumor Cell and LGALS1+ B Cell Interactions in HBV-Driven Liver Cancer

This dataset supports a study identifying glutathione peroxidase 2 (GPX2) as a mediator linking Hepatitis B virus infection to hepatocellular carcinoma progression. It contains data from single-cell analysis of HBV-positive HCC, revealing a GPX2+ cancer stem cell population and its role in recruiting immunosuppressive LGALS1+ B cells via the CCL26-CCR3 axis. The findings position the GPX2-B cell axis as a potential therapeutic target.

Use Cases

• Analyze the correlation between GPX2 expression levels and MYC/CD44 expression in cancer stem cell populations.
• Investigate the CCL26-CCR3 signaling axis data to model immune cell recruitment in the tumor microenvironment.
• Examine LGALS1+ B cell state data to predict adverse patient outcomes in hepatocellular carcinoma.
• Use the dataset to validate in vivo findings linking GPX2 overexpression to accelerated tumorigenesis.

Strengths

• Data is derived from single-cell analysis of HBV-positive hepatocellular carcinoma, providing cellular-level insights.
• The dataset is associated with a study that includes in vivo validation of the GPX2-B cell axis mechanism.
• It is shared under a permissive CC BY 4.0 license, facilitating reuse and analysis.

Limitations

• The dataset is very small at 10.4 KB, indicating limited scope and likely a summary or supplementary table rather than raw experimental data.
• Specific structural details like row count, column names, and sample data are unavailable, hindering immediate analytical utility.
• The data is focused on a specific molecular mechanism in HBV-driven HCC, limiting generalizability to other cancer types or etiologies.

Provenance

Source

figshare

Collection Method

Single-cell analysis of HBV-positive hepatocellular carcinoma samples, as described in the associated study.

Freshness

Last updated on 2026-03-20.