Gut Microbial IgA Coating in Infants from Farming and Urban Cohorts

30 stool samples from 9 Old Order Mennonite and 21 Rochester infants were analyzed using IgA-SEQ to assess gut microbiome IgA coating levels at an average age of 6 months. The dataset, authored by Joseph J. Campo and last updated in April 2026, compares microbial IgA coating between populations with low (less than 2%) and high (40%) allergy prevalence. It includes associations between specific bacterial taxa coating and allergic outcomes, as well as data on human milk IgA-binding.

Use Cases

• Identify microbial taxa associated with allergic outcomes based on IgA coating levels described for P. melaninogenica, Pasteurellaceae, and R. gnavus.
• Study the relationship between infant age and IgA coating based on described associations with Atopobium, Bifidobacterium, Coprococcus, and Corynebacterium.
• Compare gut microbiome IgA coating between traditional farming and urbanized infant populations as described in the cohort study.
• Investigate the role of breastfeeding and human milk IgA response to commensals like B. infantis based on the described experimental assessments.

Strengths

• Includes data from two distinct cohorts with contrasting allergy prevalence (less than 2% vs 40%).
• Contains results from specific experimental methods: IgA-SEQ on stool samples and in vitro IgA-binding assays.
• Associates IgA coating levels with specific bacterial taxa and clinical outcomes (atopic dermatitis, food allergy).

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is very small (20.2 KB), indicating limited scope.

Provenance

Source

figshare

Collection Method

Immunoglobulin A sequencing (IgA-SEQ) on infant stool samples and in vitro binding assays.

Time Range

Samples collected at an average infant age of 6 months; allergic outcomes diagnosed throughout the first 2 years.

Freshness

Last updated 2026-04-20 05:23:33; freshness should be verified.

Geography

Infants from an urbanized Rochester cohort and a traditional, agrarian Old Order Mennonite community.