Gut Microbiome Differences in Rheumatoid Arthritis by Serostatus

Eight studies published between 2016 and 2024 were systematically reviewed to analyze gut microbiome differences in rheumatoid arthritis patients based on RF and ACPA serostatus. The review, authored by Madiyar Nurgaziyev, consistently reports higher abundances of Collinsella and Blautia and lower levels of Faecalibacterium in seropositive RA, with frequent associations to reduced microbial diversity.

Use Cases

• Analyze reported abundances of Collinsella, Blautia, and Faecalibacterium to identify microbial signatures distinguishing seropositive from seronegative RA patients.
• Compare α-diversity and β-diversity findings across the eight included studies to assess consistency of microbial diversity reductions linked to ACPA-positive status.
• Map extracted data on RF and ACPA serostatus against gut microbiome composition to evaluate biomarker potential for disease subgroups.
• Synthesize results from studies using the Newcastle–Ottawa Scale (NOS) for quality assessment to highlight methodological strengths in the systematic review.

Strengths

• Findings are based on a systematic review of eight distinct studies, providing a synthesized evidence base.
• Review covers research published from 2016 to 2024, capturing nearly a decade of relevant scientific output.
• Data extraction and quality assessment were performed independently by two reviewers using the standardized Newcastle–Ottawa Scale.

Limitations

• The dataset is a 26.1 KB DOCX file containing summarized review text, not the raw tabular or sequence data from the primary studies.
• Small evidence base of only eight included studies limits statistical power and generalizability of conclusions.
• Findings for β-diversity were reported as heterogeneous across cohorts, indicating inconsistent results.

Provenance

Source

figshare, authored by Madiyar Nurgaziyev.

Collection Method

Systematic literature review from PubMed, Scopus, Web of Science, and Cochrane Library.

Time Range

Studies published between 2016 and 2024.

Freshness

Last updated March 2026, based on a search extending to July 2025.

Geography

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