Systematic Review of Gut Microbiota and Amyotrophic Lateral Sclerosis (ALS)

Debarghya Kumar Chakraborty's systematic review synthesizes evidence on the gut microbiome's role in amyotrophic lateral sclerosis (ALS). The review, published on figshare in April 2026, analyzed 61 studies from a search of 2,397 records across PubMed, Medline, Embase, Scopus, Semantic Scholar, and Google Scholar. It narratively synthesizes findings on microbial diversity, key taxa shifts, and mechanistic pathways linking dysbiosis to ALS.

Use Cases

• Literature synthesis on gut microbiome alterations in ALS based on the review's narrative findings.
• Hypothesis generation for mechanistic studies based on the described links between dysbiosis, barrier dysfunction, and immune activation.
• Designing longitudinal or interventional study protocols based on the identified gaps in causal inference.
• Meta-research on methodological trends in microbiome-ALS studies based on the analysis of 61 included papers.

Strengths

• Systematic methodology with a defined search across six major databases up to November 2025.
• Quality assessment of included studies performed using the QUADAS-2 tool.
• Synthesizes evidence from 61 human and animal studies, providing a consolidated view of the field.

Limitations

• The dataset is a 39.6 KB DOCX document, which is a text summary and not the underlying primary data.
• Row count and column-level documentation for any extracted data are absent.
• The review notes a predominance of cross-sectional designs and small sample sizes in the underlying literature, limiting causal inference.

Provenance

Source

figshare, author Debarghya Kumar Chakraborty.

Collection Method

Systematic review of literature from PubMed, Medline, Embase, Scopus, Semantic Scholar, and Google Scholar.

Time Range

Literature search conducted up to November 23, 2025; no date restrictions were applied.

Freshness

Last updated 2026-04-13 05:20:48.

Geography

Studies likely include global research, but specific geographic coverage is not stated.