Hand-Foot Skin Reaction Reports for 11 VEGFR-TKIs from FAERS (2004-2025)

From Q1 2004 to Q2 2025, this dataset contains 8,668 reports of Hand-Foot Skin Reaction (HFSR) associated with Vascular Endothelial Growth Factor Receptor Tyrosine Kinase Inhibitors (VEGFR-TKIs), analyzed from the FDA Adverse Event Reporting System (FAERS). The pharmacovigilance study by Jinhan Chen performed disproportionality analyses using ROR, PRR, MGPS, and BCPNN algorithms to quantify safety signals. Patient demographics, time-to-onset, and clinical outcomes were assessed.

Use Cases

• Compare HFSR signal strength across 11 VEGFR-TKIs based on disproportionality analyses.
• Analyze patient demographics and time-to-onset patterns for HFSR events.
• Investigate clinical outcomes, such as hospitalization rates, associated with HFSR reports.

Strengths

• Contains 8,668 HFSR reports for analysis.
• Covers a long time range from Q1 2004 to Q2 2025.
• Analyzes 11 specific VEGFR-TKIs using four disproportionality algorithms.
• Includes subgroup analysis by patient sex and median time-to-onset data.

Limitations

• Row count and column-level documentation are unknown, requiring manual inspection after download.
• Data may reflect reporting bias inherent to the FAERS spontaneous reporting system.

Provenance

Source

FDA Adverse Event Reporting System (FAERS) database.

Collection Method

Pharmacovigilance study involving data cleaning and disproportionality analysis.

Time Range

Q1 2004 to Q2 2025.

Freshness

Last updated 2026-06-04 04:30:41.