HBx-YBX3 Protein Interaction Data for Hepatitis B Virus Replication

A 774.1 KB dataset by Mel Veen Boo, last updated in May 2026, documenting the interaction between the Hepatitis B Virus regulatory protein HBx and the host factor YBX3. The data likely contains results from immunoprecipitation-coupled mass spectrometry, co-immunoprecipitation validation, and CRISPR/Cas9 knockout experiments conducted in HepG2-hNTCP cells.

Use Cases

• Validate HBx protein interactions based on immunoprecipitation-coupled mass spectrometry data.
• Analyze the impact of YBX3 knockout on viral replication metrics like cccDNA and pgRNA.
• Model proviral feedback loops based on YBX3 mRNA and protein upregulation during infection.
• Identify potential antiviral targets based on host factor dependency data.

Strengths

• Dataset is licensed under CC-BY-4.0, facilitating open reuse.
• Description provides specific methodological details, including CRISPR/Cas9 knockout and genetic rescue experiments.
• The file size is 774.1 KB, indicating a focused and manageable dataset.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is a single DOCX file; data extraction and formatting may require manual effort.

Provenance

Source

figshare

Collection Method

Immunoprecipitation-coupled mass spectrometry, co-immunoprecipitation, CRISPR/Cas9 knockout, and subcellular fractionation.

Freshness

Last updated 2026-05-22 05:36:30; freshness should be verified.