Hepatic Zinc Deficiency and Acute Phase Response in Alcohol-Associated Hepatitis

A transcriptomic zinc signature derived from 11 public datasets, validated in vitro, examining the role of zinc deficiency in alcohol-associated hepatitis. The dataset was created by Scott A. Read and published on figshare under a CC-BY-4.0 license. It was last updated on March 18, 2026.

Use Cases

• Validate the nine-gene zinc signature based on metallothionein genes in other liver disease cohorts.
• Analyze the correlation between zinc deficiency and down-regulation of acute phase response genes like SAA1, CRP, and C9.
• Model the impact of zinc depletion on macrophage responses to LPS stimulation using in vitro data.
• Investigate potential therapeutic targets for improving acute-phase responses in patients with alcohol-associated hepatitis.

Strengths

• Dataset is based on 11 publicly available transcriptomic datasets, providing a broad initial analysis.
• Includes in vitro validation data from primary immune cell and hepatocyte models.
• File size is 7.3 MB, indicating a manageable download and analysis scope.

Limitations

• Row count and specific column definitions are unknown, limiting suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• Data may reflect bias inherent to the specific public datasets aggregated for the signature.

Provenance

Source

figshare, author Scott A. Read.

Collection Method

Bioinformatic analysis of public datasets combined with in vitro experimental validation.

Freshness

Last updated 2026-03-18 07:36:48; freshness should be verified.