Table 2_High-protein supplementation in critically ill patients: a systematic review, meta

18 randomized controlled trials and 8 meta-analyses were included in this systematic review and meta-analysis investigating high-protein supplementation in critically ill patients. The analysis, conducted by Zhiming You and registered as CRD420250652684, found no significant association between high-protein supplementation and overall mortality. Long-term intervention for more than 14 days was associated with a slight increase in overall mortality.

Use Cases

• Conducting a meta-analysis on clinical trial outcomes based on aggregated data from 18 RCTs and 8 meta-analyses.
• Performing subgroup analysis to explore the effects of high-protein versus conventional protein supplementation.
• Applying Trial Sequential Analysis (TSA) to verify the robustness of evidence in nutritional support research.
• Assessing bias risk in clinical studies using the ROB 2.0 and AMSTAR-2 tools as described in the methodology.

Strengths

• Includes data from 18 randomized controlled trials and 8 meta-analyses, providing a substantial evidence base.
• Employs multiple analytical methods including meta-analysis, subgroup analysis, umbrella review, and Trial Sequential Analysis.
• Uses standardized tools for bias assessment: the Revised Cochrane’s Risk of Bias tool (ROB 2.0) and the AMSTAR-2 tool.

Limitations

• The underlying data tables and column-level documentation are not provided, requiring manual inspection after download.
• Row count and specific data structure are unknown, which may limit suitability assessment for direct computational analysis.
• The file format is DOCX, which may require conversion for structured data analysis.

Provenance

Source

figshare, authored by Zhiming You.

Collection Method

Systematic review and meta-analysis of studies from PubMed, Web of Science, Cochrane Library, and Embase up to April 1, 2026.

Time Range

Studies included up to April 1, 2026.

Freshness

Last updated 2026-05-21 04:35:59; freshness should be verified.