Zonula Occludens Toxin Epitope Predictions for Acinetobacter Baumannii Vaccine Design

An 8.0 KB Excel file contains immunoinformatic profiling results for the Zonula occludens toxin (Zot) virulence factor in Acinetobacter baumannii. Payam Benyamini authored this dataset, which was last updated on June 4, 2026. The analysis includes comparative sequence data from 62 full-length Zot homologs and high-resolution epitope mapping for B-cell and T-cell recognition.

Use Cases

• Prioritize conserved epitopes for vaccine development based on predicted MHC Class I and II binding motifs.
• Analyze structural constraint and sequence diversity across bacterial lineages using comparative sequence data.
• Evaluate Zot as a target for humoral immune engagement based on mapped B-cell–accessible regions.

Strengths

• Analysis is based on 62 full-length Zot homologs, providing a comparative evolutionary framework.
• High-resolution epitope mapping identifies conserved MHC binding motifs, particularly within a C-terminal domain.
• Data is shared under a CC-BY-4.0 license, permitting reuse with attribution.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is very small (8.0 KB), indicating limited scope, likely containing summary results rather than raw sequence data.

Provenance

Source

figshare

Collection Method

Integrated immunoinformatic and evolutionary framework applied to protein sequences.

Freshness

Last updated 2026-06-04 05:42:54; freshness should be verified.