EAE Mouse Model: Hippocampal Neuronal Data for PTSD-Like Phenotypes

Experimental data from a mouse model links hippocampal neuronal hypoexcitability to PTSD-like symptoms in multiple sclerosis. The dataset, created by Xinghua Zhong and last updated in May 2026, includes results from morphometric analysis, whole-cell recordings, chemogenetic manipulation, and single-nucleus RNA sequencing. It is shared under a CC-BY-4.0 license on figshare.

Use Cases

• Analyzing the relationship between somatic atrophy and firing gain in neurons based on morphometric and electrophysiological data.
• Investigating neuroimmune transcriptional shifts based on single-nucleus RNA sequencing results showing immune and apoptosis-related gene signatures.
• Modeling the effect of chemogenetic reactivation on behavioral deficits based on the described fear extinction and generalization tests.

Strengths

• Includes multi-modal experimental data from four distinct methodologies described in the research.
• Shared under a permissive CC-BY-4.0 license, allowing for broad reuse.
• Dataset is small (116.7 KB), facilitating quick download and initial inspection.

Limitations

• Row count and specific column definitions are unknown, requiring manual inspection after download.
• Description metadata is limited; actual data quality and structure require verification.
• Data is from a controlled mouse model, which may limit direct translation to human clinical contexts.

Provenance

Source

figshare

Collection Method

Data generated through laboratory experiments including morphometric analysis, whole-cell recordings, chemogenetic manipulation, and single-nucleus RNA sequencing on an EAE mouse model.

Freshness

Last updated 2026-05-20 13:23:09