Homocysteine and Cognitive Function in Depression: Meta-Analysis Results

A systematic review and meta-analysis by Xiaotong Liu, last updated in May 2026, investigates the association between homocysteine levels and cognitive function in patients with depression. The work synthesizes results from 13 studies involving 1,269 patients, finding a significant inverse correlation. The document reports meta-analysis results including correlation coefficients and standardized mean differences.

Use Cases

• Validate the association between homocysteine levels and cognitive impairment in depression based on the reported meta-analysis results.
• Inform the design of prospective clinical studies on biomarkers for cognitive assessment in depression.
• Support literature reviews on biochemical correlates of cognitive function in psychiatric disorders.

Strengths

• Includes results from a meta-analysis of 13 studies and 1,269 patients.
• Reports specific statistical findings, including a correlation coefficient (r = -0.41) and standardized mean differences (SMD = -0.37, SMD = 2.44).
• Describes a systematic search across seven major databases, including Chinese sources.

Limitations

• The dataset is a single 88.6 KB DOCX file containing summary results, not the underlying patient-level or study-level data.
• Row count and column-level documentation for any potential tabular data within the document are unknown.
• Description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

figshare

Collection Method

Systematic review and meta-analysis of published studies.

Time Range

Studies included from database inception to December 2025.

Freshness

Last updated 2026-05-13 05:57:16; freshness should be verified.