Table 2_HSF1 modulates lipid metabolism and ferroptosis in sarcopenia: a novel diagnostic

A research document by Dalu Cheng, last updated April 30, 2026, presents bioinformatics and experimental findings on ferroptosis-relevant genes in sarcopenia. The 12.0 KB file contains results from RNA-seq analyses of public datasets GSE25941 and GSE9103, identifying six hub genes as diagnostic biomarkers. The study highlights HSF1 as a key gene and suggests potential therapeutic agents via molecular docking.

Use Cases

• Identifying diagnostic biomarkers for sarcopenia based on the six hub ferroptosis-relevant genes (ACSL6, CDKN1A, ATG4D, DECR1, HSF1, MIB1).
• Evaluating machine learning model performance for biomarker screening based on the described use of LASSO, SVM, KNN, XGBoost, and NNET algorithms.
• Investigating the role of HSF1 in lipid metabolism and ferroptosis pathways in muscle cells based on the described functional experiments in C2C12 myoblasts.
• Assessing potential therapeutic compounds like quercetin and cycloheximide based on the molecular docking results targeting HSF1.

Strengths

• Identifies six hub genes with reported AUC values greater than 0.8 for diagnostic robustness.
• Includes experimental validation in C2C12 myoblast cell lines to support bioinformatics findings.
• Released under a CC-BY-4.0 license, permitting broad reuse with attribution.

Limitations

• The dataset is a 12.0 KB DOCX document, which is a very small text file likely containing summary results rather than raw data.
• Row count and column-level documentation are unknown, limiting suitability assessment for direct computational analysis.
• The data is derived from specific public datasets (GSE25941, GSE9103); its applicability to other populations or conditions is unclear.

Provenance

Source

figshare

Collection Method

Bioinformatics analysis of RNA-seq data from public datasets GSE25941 and GSE9103, combined with experimental validation.

Time Range

Publication date suggests analysis was conducted prior to 2026.

Freshness

Last updated 2026-04-30 07:35:04

Geography

Geographic scope of the underlying public datasets is not specified.