Huoxue Jiegu Compound Capsule Mechanisms for Tibial Fracture Healing

A dataset from a 2026 study by Weisong Lu investigating the molecular mechanisms of a traditional Chinese medicine capsule on bone repair. It integrates network pharmacology, molecular docking, dynamics simulations, and in vivo rabbit model experiments. The data likely contains results identifying 209 candidate compounds, 185 overlapping targets, and validation of angiogenesis-related gene expression.

Use Cases

• Identify key therapeutic targets for fracture healing based on the 185 overlapping targets identified.
• Validate molecular docking predictions using the results from 100-ns molecular dynamics simulations.
• Analyze angiogenesis-related signaling pathways based on enrichment in HIF-1, PI3K-Akt, and FoxO pathways.
• Correlate in vivo vascular density measurements with gene expression levels of AKT1, STAT3, IL6, and EGFR.

Strengths

• Integrates multiple methodologies including network pharmacology, molecular docking, and in vivo validation.
• Identifies specific hub targets (AKT1, STAT3, IL6, BCL2, EGFR, JUN) and 209 candidate compounds.
• Released under a permissive CC-BY-4.0 license for open reuse.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is very small (11.2 KB), indicating limited scope, likely containing summary results rather than raw experimental data.

Provenance

Source

figshare

Collection Method

Generated from an integrative study combining network pharmacology, computational simulations, and in vivo rabbit tibial defect model experiments.

Freshness

Last updated 2026-05-11 05:29:07; freshness should be verified.