Klebsiella pneumoniae Hybrid Plasmids: Genetic Diversity and Virulence from 32 Isolates

Whole-genome sequencing data for 32 Klebsiella pneumoniae isolates from patients and environmental surfaces in eight Russian hospitals. The dataset includes analysis of 295 global hybrid plasmids, their virulence and antibiotic resistance genes, and mouse lethality assay results for 7 isolates. Author Svetlana Kovalchuk published the data on figshare under a CC-BY-4.0 license.

Use Cases

• Cluster analysis of hybrid plasmid sequences based on replicon type, ARGs, and virulence genes mentioned in the description.
• Assessing the association between hybrid plasmid carriage and hypervirulent phenotype using mouse lethality assay data.
• Studying the genetic diversity of Klebsiella pneumoniae isolates belonging to sequence types ST147, ST395, and ST11.
• Analyzing the co-occurrence of virulence genes (iucABCD, iutA, rmpA2) and antibiotic resistance genes like blaOXA-48 on plasmids.

Strengths

• Includes whole-genome sequencing data for 32 bacterial isolates.
• Analyzes a global population of 295 hybrid plasmids.
• Contains experimental virulence data from mouse lethality assays for 7 isolates.

Limitations

• Row count and column-level documentation are unknown, requiring manual inspection after download.
• The dataset is small at 12.3 KB, indicating limited scope.
• Data may reflect geographic bias inherent to the sample collection from Russian hospitals.

Provenance

Source

figshare

Collection Method

Whole-genome sequencing of clinical and environmental isolates, mouse lethality assays, and bioinformatic cluster analysis.

Freshness

Last updated 2026-04-29 06:02:26; freshness should be verified.

Geography

Eight hospitals in Russia