Hyperglycemia-Induced Immune Tolerance in Human Alveolar Macrophages

Primary human alveolar macrophages from diabetic patients were analyzed to study hyperglycemia-induced immune tolerance. The dataset likely contains results from cytokine secretion, phagocytosis, metabolomics, RNA-seq, ATAC-seq, and CUT&Tag assays. The data was uploaded by Jiang Wang on figshare in May 2026.

Use Cases

• Analyze metabolic reprogramming based on Seahorse and LC-MS metabolomics data mentioned in the description
• Study epigenetic modifications based on H3K4me3 CUT&Tag and ATAC-seq chromatin accessibility data
• Investigate immune-tolerant phenotypes based on cytokine secretion and phagocytosis assay results
• Identify candidate immunomodulatory targets based on transcriptional analysis of inflammation, autophagy, and apoptosis-related genes

Strengths

• Data is derived from primary human alveolar macrophages, providing a clinically relevant model
• Includes multi-modal analysis covering immune phenotypes, metabolism, transcription, and epigenetics
• Licensed under CC-BY-4.0, allowing for open reuse

Limitations

• Column-level documentation is absent; field semantics must be inferred after download
• Row count is unknown, which may limit suitability assessment
• The dataset is 17.0 KB, indicating a limited scope likely focused on summary or key results

Provenance

Source

figshare

Collection Method

Primary human alveolar macrophages were isolated from patients with diabetes; an in vitro hyperglycemia-induced immune memory model was established.

Freshness

Last updated 2026-05-07 04:45:57