Common Genes Associated with Diabetic Nephropathy and Retinopathy

A 2026 study by Juan He identified 206 common genes and diagnostic biomarkers for diabetic nephropathy (DN) and diabetic retinopathy (DR). The dataset, shared on figshare, contains results from differential expression and enrichment analyses of transcriptome data GSE185011. It includes 6 diagnostic genes for DN and 4 for DR, along with constructed TF-mRNA-miRNA regulatory networks.

Use Cases

• Identifying potential diagnostic biomarkers for diabetic nephropathy based on the 6 identified genes (METTL27, NMNAT2, TTC25, GAS6, ATP4A, ZNF223).
• Investigating shared molecular pathways between diabetic nephropathy and retinopathy based on the 206 intersecting common genes.
• Analyzing immune cell infiltration differences in diabetic complications based on the described changes in central memory CD4 T cells and activated B cells.
• Studying gene regulatory networks in diabetic complications based on the constructed TF-mRNA-miRNA networks.

Strengths

• Identifies a specific set of 206 common genes from intersecting 526 and 1,059 differentially expressed gene lists.
• Reports concrete diagnostic gene counts: 6 for diabetic nephropathy and 4 for diabetic retinopathy.
• Includes results from multiple analytical methods (LASSO, GSEA, immune infiltration analysis) as described.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is small (70.3 KB), indicating limited scope, likely containing summary results rather than raw expression data.

Provenance

Source

figshare, author Juan He.

Collection Method

Analysis of transcriptome dataset GSE185011 using differential expression, enrichment, LASSO, and network analysis.

Freshness

Last updated 2026-04-28 05:24:45; freshness should be verified.