Drug Repurposing Screen for Efflux Inhibitors in Candida albicans

Débora Marques published a dataset on figshare in May 2026 detailing an in silico drug repurposing study for Candida albicans. The dataset likely contains results from screening 245 predicted membrane transport proteins and 59 selected drugs for efflux-modulating potential. Findings include identification of drugs like amlodipine and fluoxetine as potential efflux inhibitors.

Use Cases

• Identifying candidate efflux inhibitors based on homology screening of membrane transport proteins.
• Evaluating adjuvant effects of repurposed drugs on fluconazole activity.
• Analyzing fluorometric assay results for ethidium bromide accumulation.
• Comparing minimum inhibitory concentration (MIC) values for selected drugs.
• Screening approved drugs associated with membrane transport functions for antifungal research.

Strengths

• The dataset is derived from a structured methodology involving screening 245 predicted membrane transport proteins.
• Results include specific quantitative findings, such as a MIC of 2 mg/L for miltefosine and a four-fold decrease in fluconazole MIC for amlodipine.
• The dataset is openly licensed under CC-BY-4.0.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is small (165.5 KB), indicating limited scope.

Provenance

Source

figshare

Collection Method

In silico screening from DrugBank database followed by in vitro assays.

Freshness

Last updated 2026-05-18 05:31:28; freshness should be verified.