ISR-Related Prognostic Genes in High-Grade Serous Ovarian Cancer

A 2026 study by Qian Li identifies four prognostic genes (NUP35, CASP3, BAG5, DNAJB1) for high-grade serous ovarian cancer (HGSOC). The dataset likely contains results from integrated analyses using Mendelian randomization, single-cell RNA sequencing, and bulk RNA sequencing. It was published on figshare under a CC-BY-4.0 license.

Use Cases

• Validating prognostic gene signatures for HGSOC based on the identified genes NUP35, CASP3, BAG5, and DNAJB1.
• Investigating drug sensitivity correlations, such as the link between DNAJB1 expression and NPK76-II-72–1, as mentioned in the description.
• Analyzing gene expression dynamics during epithelial cell differentiation using the single-cell RNA sequencing results referenced.
• Building or benchmarking risk models for patient stratification into high- and low-risk groups based on the described methodology.

Strengths

• Identifies four specific prognostic genes (NUP35, CASP3, BAG5, DNAJB1) with validation via multiple techniques.
• Results are validated through RT-qPCR, western blotting, and immunohistochemical staining as described.
• Published under a permissive CC-BY-4.0 license, facilitating reuse.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is very small (9.9 KB), indicating limited scope, likely containing summary results rather than raw sequencing data.

Provenance

Source

figshare, author Qian Li.

Collection Method

Integrated analysis of HGSOC- and ISR-related data using differential expression, Mendelian randomization, univariate Cox analyses, and single-cell RNA sequencing.

Freshness

Last updated 2026-05-05 05:25:11; freshness should be verified.